Can we stop neuroinflammation in time?

This question is important. Like many other physiological processes, neuroinflammation has we stop in different stages. Transient neuroinflammation Chronic neuroinflammation Neuroglial sealing neuroinflammation Neuroau immunity Where should we intervene? At the first stage. It’s about identifying those factors that may cause temporary neuroinflammation and treating them before they become chronic inflammation, because once glial cells are “imprinted,” they are no longer able to return to their resting state. They are extremely sensitive to any immune activating signals from the periphery. As you can imagine, prognosis and clinical expectations can change dramatically.

But how does neuroinflammation occur?

At this point, you may be wondering how activation of glial cells occurs, since they are located within the brain and are therefore “protected” by the blood-brain barrier, the BBB. The first thing we have to know is that this is not an Poland Mobile Number Database impenetrable barrier, but a very selectively permeable membrane, and the astrocytes are responsible for filtering what can pass to the other side. Therefore, they allow the penetration of oxygen and food to the glucose neurons, but they try to prevent the entry of inflammatory substances produced by the body. This is the normal situation. But things may change. Do you remember how many times we talked about intestinal hyperpermeability? Likewise, the blood-brain barrier deteriorates, allowing inflammatory substances to pass through, leading to the activation of glial cells.

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This activation can be accomplished through

A variety of mechanisms. Passive Diffusion Following Robust Immune Activity Keep in mind that the blood-brain barrier is not completely impenetrable and immune messengers can cross and affect the brain, primarily the Albania Phone Number List hypothalamus. Inflammatory mediators are actively transport across the blood-brain barrier. Vascular endothelium releases glial cell activators. Activation by the vagus nerve. These are complex mechanisms. What’s really important, and what you have to know, is how you can act to prevent this activation, or if it has already occurre, to mitigate its effects so that it doesn’t evolve from transient neuroinflammation to chronic inflammation. That’s what I’m going to talk to you about now. It is important to identify it to mitigate its effects and ensure it does not progress from temporary neuroinflammation to chronic inflammation.

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