What Is Migraine and What Is Histamine. Part Ii

In What is migraine and what is histamine. Part I we discovered that histamine is involved in the condition of migraine. We also describe certain relevant data that help us distinguish types of migraine according to their symptomatology and their relationship with histamine. Thus we talk about central migraines, trigeminal migraines and peripheral migraines. After some time for reflection, let’s move on to describe them. It may be accompanied by associated immune activity : feeling of fever, changes in appetite, changes in mood. Lastly, this type of migraine is associated with mucosal inflammation and intestinal dysbiosis. Much of the amines consumed are degraded by the DAO of commensal bacteria.

Types of migraine and their relationship with histamine

Central migraines They are those caused by the release of histamine from the brain neurons themselves. Since histamine in the central nervous system serves to activate and wake us up and is inhibited by darkness, it is the typical migraine Vietnam WhatsApp Number Data that improves with darkness and calm. It worsens with stress, menstruation or mental overwork, three processes where methylation is involved. As we discussed in What is a migraine and what is histamine. Part I , methylation is the main pathway of histamine degradation in the CNS. There are other symptoms associated with methylation problems . Methodical people, with poor tolerance to stimulants, sensory hypersensitivity – tinnitus for example – and who tend to work poorly under pressure. Don’t worry, I promise an article on methylation soon.

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Trigeminal migraines

Mast cells – immune cells – are found in large numbers in the dura mater. And in close proximity to the nociceptive afferent fibers of the trigeminal nerve. Through various publications (Moskowitz et al Nature medicine, 2002), certain types Ecuador WhatsApp Number List of migraine are attributed to a sterile local meningeal inflammation. Endogenous histamine or foods with histamine can play an important role in this since mast cells are great releasers of it. Therefore, this type of migraines has the following characteristics: They follow the course of the trigeminal nerve. They are accompanied by symptoms of peripheral sensitization : negative symptoms such as hypoesthesia, loss of functionality or more common symptoms such as ectopic activity, hyperalgesia and allodynia.

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